Project Name :
Epidemiological, Clinical and Laboratory Study of Helicobacter Pylori in Georgia
Donor Organization :
BTEP&ISTC
Budget:
300000
Grant number :
BTEP (#96) ISTC (#1195)
Research Direction :
8 Medical Sciences
Sub Direction :
8-331 Epidemiology
Keyword(s) :
Helicobacter, Epidemiology
Description :
During 2007–2008, we prospectively recruited 390 subjects with gastrointestinal symptoms
referred to five tertiary care centers for diagnostic upper endoscopy. We administered a questionnaire on
potential risk factors and tested patients using three diagnostic tests: gastric biopsies underwent
histological evaluation and rapid urease test (CLO test), and an ELISA was used to detect IgG against H.
pylori in serum. We defined a case as having two or more positive results from the three available tests.
Univariate and multivariate logistic regression analyses were performed.
Results: Overall, 217 (56%) patients met the study case definition. Subjects diagnosed with cancer had
the highest rate of H. pylori infection (62%), followed by those with gastritis (55%), and ulcer (54%). Age
>30 years (adjusted odds ratio (aOR 2.6, 95% confidence interval (CI) 1.6–4.3) and residing in the capital
city (aOR 0.6, 95% CI 0.4–0.9) were significantly associated with infection.
In this large cohort with gastrointestinal symptoms, only age >30 years and living in the
capital were significant factors associated with infection. Lower SES, less education, and crowding did
not confer an increased risk, in contrast to the findings of previous studies. Population-based studies are
needed to identify potential routes and risk factors of H. pylori infection in ROG.
Duration :
01/03/2005 - 28/02/2009
Project Leader :
No leader
Project manager :
Project participant(s) :
Dimitri Kordzaia
01/03/2005 - 28/02/2009
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